PE22-28 – 10mg – Premixed Pen

Key Functions & Benefits

• Mechanism of Action: PE-22-28 inhibits the TREK-1 potassium channel (IC_50=0.12″nM” ), which helps regulate neurotransmitter release and neuronal excitability.
  According to research published on PMC (via the National Institutes of Health), PE-22-28 is a potent and selective inhibitor of the TREK-1 (TWIK-related K+ channel 1) potassium channel.
• TREK-1 Inhibition: By blocking these channels, the peptide increases neuronal excitability and synaptic transmission in brain regions associated with mood regulation, such as the hippocampus.
• Neurogenesis: Preclinical studies on MedChemExpress indicate that PE-22-28 induces hippocampal neurogenesis (growth of new neurons) and synaptogenesis (formation of new synapses) in as little as four days.
• BDNF Mimetic: Revolution Health & Wellness describes it as a BDNF (Brain-Derived Neurotrophic Factor) mimetic, as it can activate TrkB receptors to support brain repair and emotional resilience.
• Antidepressant Effects: Research in mouse models indicates it can act within days—faster than traditional antidepressants—to reduce depressive-like behaviors.
• Neuroprotection and Memory: Studies show the peptide increases hippocampal neurogenesis and synaptic plasticity (synaptogenesis), which may boost memory.
• Stroke Recovery: In animal models, PE-22-28 has been shown to reduce neuronal apoptosis (cell death) after ischemia and improve motor/cognitive function post-stroke.